Author

J. R. van Senten

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

H. Bräuner-Osborne· 1 shared J. M. Mathiesen· 1 shared M. Bouvier· 1 shared M. F. Pedersen· 1 shared S. D. Seiersen· 1 shared T. C. Moller· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperPharmacology & Toxicology

H. Bräuner-Osborne

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1 paper

Recent·Most cited

Pharmacology & ToxicologybioRxivJan 8, 2020

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells

T. C. Moller, M. F. Pedersen, J. R. van Senten…·H. Bräuner-Osborne

This study uses CRISPR/Cas9 to knockout GRK2 and GRK3 in HEK293 cells to assess their roles in μ-opioid receptor internalization and β-arrestin2 recruitment, finding GRK2 more critical than GRK3.

DOI 10.1038/s41598-020-73674-0

genetic perturbation / CRISPRcell type annotation