M. Bouvier

Calcium signals natural transformation in Acinetobacter baumannii

This paper identifies calcium as a key inducer of natural transformation in Acinetobacter baumannii, revealing both transcriptional and structural mechanisms by which calcium activates type IV pilus function.

MRAP2 modifies signaling and oligomerization state of the melanocortin-4 receptor

This study shows that MRAP2 modifies MC4R signaling and oligomerization, enhancing G protein signaling while reducing beta-arrestin2 recruitment and receptor internalization.

Multiple triggers converge to preferential effector coupling in the CB2R through a complex allosteric communication network

The paper investigates how multiple triggers on an allosteric communication network influence preferential coupling of the CB2R to Gi2 over β-arrestin1, revealing insights into GPCR signaling mechanisms.

The G protein-coupled receptor TBXA2R activates ERMs to control cell motility and invasion of triple-negative breast cancer cells.

CD8 memory precursor cells generation is a continuous process

The paper identifies that memory precursor cells are continuously generated over time following acute infection, with increased numbers and effector gene expression observed later.

Evidence for close molecular proximity between reverting and undifferentiated cells

The paper characterizes reverting cells by comparing their molecular state to undifferentiated cells using single-cell transcriptomic data and finds they return to an earlier molecular state with minimal differences.

Computationally designed GPCR quaternary structures bias signaling pathway activation

The paper designs GPCR quaternary structures to bias signaling pathway activation and identifies a conformational switch controlling G protein vs β-arrestin recruitment.

Dissecting the allosteric networks governing agonist efficacy and potency in G protein-coupled receptors

The paper integrates residue-level pharmacology data with structural contact data to uncover allosteric networks that govern ligand efficacy and potency in GPCRs.

Common coupling map advances GPCR-G protein selectivity

The paper creates a common coupling map of GPCR-G protein interactions by integrating multiple datasets, revealing selectivity and co-coupling patterns.

Interphase microtubule disassembly is a signaling cue that drives cell rounding at mitotic entry.

The paper identifies microtubule disassembly as a cell-cycle signal that activates ERMs and drives cell rounding at mitotic entry through a signaling network involving GEF-H1 and Ect2.

Vasopressin V2 is a promiscuous G protein-coupled receptor that is biased by its peptide ligands

The paper shows that the vasopressin V2 receptor activates multiple G proteins and that its signaling can be biased by ligand structure.

Diverse chemotypes drive biased signaling by cannabinoid receptors

This study identifies chemotype-specific biased signaling in cannabinoid receptors by analyzing ligand-induced signaling cascades.

Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis

This study shows Barbadin enhances FPR2-mediated ROS production in neutrophils without affecting receptor endocytosis, suggesting AP2 plays a role in ROS release.

Effector membrane translocation biosensors reveal G protein and β-arrestin coupling profiles of 100 therapeutically relevant GPCRs

The paper develops EMTA biosensors to profile G protein and β-arrestin coupling of 100 GPCRs, revealing diverse signaling profiles and drug-target interactions.

Discovery of Plasmodium falciparum SR12 as a GOLD-Domain seven transmembrane protein regulating GPCR trafficking in mammalian cells

The paper identifies Plasmodium falciparum SR12 as a GOST protein that promotes GPCR trafficking in mammalian cells through structural analysis and functional assays.

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells

This study uses CRISPR/Cas9 to knockout GRK2 and GRK3 in HEK293 cells to assess their roles in μ-opioid receptor internalization and β-arrestin2 recruitment, finding GRK2 more critical than GRK3.

Genetically encoded intrabody sensors illuminate structural and functional diversity in GPCR-β-arrestin complexes

This study uses genetically encoded intrabody sensors to reveal structural and functional diversity in GPCR-β-arrestin complexes, showing distinct functional outcomes across different receptors.