Structural models of full-length JAK2 kinase
P. Ayaz, H. Hammaren, J. Raivola, D. Sharon, S. Hubbard, O. Silvennoinen, Y. Shan, D. Shaw
This study presents structural models of full-length JAK2 in active and inactive forms, revealing how the V617F mutation disrupts autoinhibition and promotes constitutive activity.
bioRxiv · Aug 7, 2019 · PreprintBiochemistry