Author

D. Sharon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. G. Hendricks· 1 shared A. Mason· 1 shared A. R. Chaudhary· 1 shared A. Thiesen· 1 shared D. Shaw· 1 shared E. N. P. Prowse· 1 shared E. Wine· 1 shared H. Abofayed· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperBiophysics

A. G. Hendricks

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10-/- mouse model of inflammatory bowel disease

H. Armstrong, M. Rahbari, H. Park, D. Sharon, A. Thiesen, N. Hotte, N. Sun, H. Syed, H. Abofayed, W. Wang, K. Madsen, E. Wine, A. Mason

This study investigates the role of mouse mammary tumor virus (MMTV) in colitis and dysbiosis in IL-10-/- mice, finding that MMTV contributes to disease severity and that antiretroviral therapy reduces MMTV load and improves symptoms.

bioRxiv · Jan 26, 2023Microbiology

Huntingtin S421 phosphorylation increases kinesin and dynein engagement on early endosomes and lysosomes

E. N. P. Prowse, A. R. Chaudhary, D. Sharon, A. G. Hendricks

This study shows that phosphorylation of huntingtin at S421 increases kinesin and dynein engagement on early endosomes and lysosomes, leading to longer and more processive organelle movement.

bioRxiv · May 27, 2022Biophysics

A mean-field approach for modeling the propagation of perturbations in biochemical reaction networks

M. Przedborski, D. Sharon, S. Chan, M. Kohandel

The paper develops a mean-field model to predict the temporal behavior of protein expression in response to perturbations in biochemical networks, validated against RNA sequencing data.

bioRxiv · Jan 26, 2021Pharmacology & Toxicology

Structural models of full-length JAK2 kinase

P. Ayaz, H. Hammaren, J. Raivola, D. Sharon, S. Hubbard, O. Silvennoinen, Y. Shan, D. Shaw

This study presents structural models of full-length JAK2 in active and inactive forms, revealing how the V617F mutation disrupts autoinhibition and promotes constitutive activity.

bioRxiv · Aug 7, 2019 · PreprintBiochemistry