Focal adhesion kinase confers pro-migratory and anti apoptotic properties and is a potential therapeutic target in Ewing sarcoma
K. Steinestel, E.-P. Jansen, M. Trautmann, U. Dirksen, J. Rehkamper, J.-H. Mikesch, J. S. Gerke, M. F. Orth, G. Sannino, E. Wardelmann, T. G. P. Grunewald, W. Hartmann
This study shows FAK promotes migration and prevents apoptosis in Ewing sarcoma via Y397 phosphorylation, suggesting FAK inhibitors could target metastasis.
bioRxiv · Apr 12, 2019Cancer Biology