Leukemic mutation FLT3-ITD is retained in dendritic cells and disrupts their homeostasis leading to expanded Th17 frequency
P. A. Flynn, M. D. Long, Y. Kosaka, J. S. Mulkey, J. L. Coy, A. Agarwal, E. F. Lind
This study shows FLT3-ITD mutations in AML retain in dendritic cells, altering their phenotype and increasing Th17 T cell frequency.
bioRxiv · Sep 19, 2023Immunology