Predicting T cell receptor antigen specificity from structural features derived from homology models of receptor-peptide-major histocompatibility complexes.
M. Milighetti, J. Shawe-Taylor, B. Chain
The paper develops a classifier to predict TCR binding using structural features from homology models of TCR-pMHC complexes, achieving comparable performance to sequence-based methods with smaller training sets.
bioRxiv · May 19, 2021Immunology