J. Slovakova

Challenging the Astral mass analyzer - up to 5300 proteins per single-cell at unseen quantitative accuracy to study cellular heterogeneity.

This paper introduces a high-throughput single-cell proteomics workflow achieving 5300 protein groups per cell with high accuracy, enabling the study of cellular heterogeneity and lineage differentiation.

Tension-dependent stabilization of E-cadherin limits cell-cell contact expansion

The paper shows that cortical tension stabilizes E-cadherin at cell-cell contacts, limiting contact expansion beyond a critical tension threshold.