An IDH-independent mechanism of DNA hypermethylation upon VHL inactivation in cancer
A. V. Artemov, S. Zhenilo, D. Kaplun, A. Starshin, A. Sokolov, A. M. Mazur, J. Szpotan, M. Gawronski, M. Modrzejewska, D. Gackowski, E. B. Prokhortchouk
This study shows that VHL inactivation causes genome hypermethylation in kidney cancer cells through 2-hydroxyglutarate accumulation, independent of IDH mutations.
bioRxiv · Dec 9, 2020Cancer Biology