Oxidants are dispensable for HIF1α stability in hypoxia
A. Kumar, M. Vaish, S. S. Karuppagounder, I. Gazaryan, J. W. Cave, A. A. Starkov, E. T. Anderson, S. Zhang, J. T. Pinto, A. Rountree, W. Wang, I. R. Sweet, R. R. Ratan
This study shows mitochondrial and cytosolic reactive oxygen species are not required for HIF1α stability under hypoxia, suggesting HIF prolyl hydroxylase inhibition could be therapeutically beneficial.
bioRxiv · May 5, 2020 · PreprintCell Biology