Author

I. R. Sweet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2 Cancer Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:metabolism & bioenergetics· 4 Organism:mouse· 4 Assay:proteomics· 4 Assay:metabolomics· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2

Frequent Co-Authors

B. M. Robbings· 4 shared J. B. Hurley· 4 shared V. Kamat· 4 shared C. M. Bisbach· 3 shared D. T. Hass· 3 shared M. Sadilek· 3 shared A. M. Rountree· 2 shared D. J. Marcinek· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersBiochemistry

B. M. Robbings

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

A Compound that Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer

T. Uo, K. K. Ojo, C. C. Sprenger, K. S. Epilepsia, B. G. K. Perera, M. Damodarasamy, S. Sun, S. Kim, H. H. Hogan, M. A. Hulverson, R. Choi, G. R. Whitman, L. K. Barrett, S. A. Michaels, L. H. Xu, , S. R. Plymate

This paper evaluates a novel antiglycolytic compound, BKIDC-1553, showing selective growth inhibition of prostate cancer cells and safety for clinical trials.

bioRxiv · Jul 1, 2023Cancer Biology

Elamipretide Improves ADP Sensitivity in Aged Mitochondria by Increasing Uptake through the Adenine Nucleotide Translocator (ANT)

G. Pharaoh, V. Kamat, S. Kannan, R. S. Stuppard, J. Whitson, M. Martin-Perez, W.-J. Qian, M. J. MacCoss, J. Villen, P. Rabinovitch, M. D. Campbell, I. R. Sweet, D. J. Marcinek

This paper shows that Elamipretide improves ADP sensitivity in aged mitochondria by enhancing ADP uptake through the ANT, leading to improved muscle and heart function.

bioRxiv · Feb 1, 2023 · PreprintPhysiology

Contemporary human H3N2 influenza A viruses require a low threshold of suitable glycan receptors for efficient infection

C. M. Spruit, I. R. Sweet, T. Bestebroer, P. Lexmond, B. Qiu, M. J. Damen, R. A. Fouchier, J. Snijder, S. Herfst, G.-J. Boons, R. P. de Vries

This study shows that recent H3N2 influenza A viruses require a low threshold of glycan receptors for efficient infection, and increasing receptor numbers beyond this threshold does not improve infection efficiency.

bioRxiv · Nov 16, 2022Microbiology

A Peptide Triple Agonist of GLP-1, Neuropeptide Y1, and Neuropeptide Y2 Receptors Promotes Glycemic Control and Weight Loss

K. S. Chichura, C. T. Elfers, T. Salameh, V. Kamat, O. G. Chepurny, A. McGivney, B. T. Milliken, G. G. Holz, S. V. Appleby, M. R. Hayes, I. R. Sweet, C. L. Roth, R. P. Doyle

The paper shows that peptide agonists of GLP-1, Y1-R, and Y2-R improve glycemic control and weight loss in rats, with Y1-R antagonism enhancing GLP-1R effects.

bioRxiv · Nov 7, 2022Pharmacology & Toxicology

Metabolic function in aging retina and retinal pigment epithelium remains robust despite vision loss

K. A. Tsantilas, W. M. Cleghorn, C. M. Bisbach, J. A. Whitson, D. T. Hass, B. M. Robbings, M. Sadilek, J. D. Linton, A. M. Rountree, A. P. Valencia, M. T. Sweetwyne, M. D. Campbell, H. Zhang, C. S. R. Jankowski, I. R. Sweet, , J. B. Hurley

This study examines metabolic changes in aging mouse retina and eyecup, finding stable glucose and glutamine metabolism despite vision loss.

bioRxiv · Apr 6, 2021Biochemistry

Fluidics System for Resolving Concentration-Dependent Effects of Dissolved Gases on Tissue Metabolism

I. R. Sweet, J. B. Hurley, V. Kamat, B. M. Robbings, K. P. Bube, S.-R. Jung, J. Kelly

This paper introduces a fluidics system to study how dissolved gases affect tissue metabolism and function, revealing new insights into oxygen consumption and hydrogen sulfide effects on insulin secretion.

bioRxiv · Mar 7, 2021Cell Biology

Succinate metabolism uncouples retinal pigment epithelium mitochondria

D. T. Hass, C. M. Bisbach, B. M. Robbings, M. Sadilek, I. R. Sweet, J. B. Hurley

The paper investigates succinate metabolism in retinal pigment epithelium and finds that succinate consumption by eyecup tissue uncouples mitochondrial ATP synthesis from respiration.

bioRxiv · Feb 10, 2021 · PreprintBiochemistry

Oxidants are dispensable for HIF1α stability in hypoxia

A. Kumar, M. Vaish, S. S. Karuppagounder, I. Gazaryan, J. W. Cave, A. A. Starkov, E. T. Anderson, S. Zhang, J. T. Pinto, A. Rountree, W. Wang, I. R. Sweet, R. R. Ratan

This study shows mitochondrial and cytosolic reactive oxygen species are not required for HIF1α stability under hypoxia, suggesting HIF prolyl hydroxylase inhibition could be therapeutically beneficial.

bioRxiv · May 5, 2020 · PreprintCell Biology

Succinate can shuttle reducing power from the hypoxic retina to the O2-rich pigment epithelium.

C. M. Bisbach, D. T. Hass, B. M. Robbings, A. M. Rountree, M. Sadilek, I. R. Sweet, J. B. Hurley

The paper shows that succinate shuttles reducing power from the hypoxic retina to the O2-rich pigment epithelium via a malate/succinate cycle.

bioRxiv · Jan 17, 2020Biochemistry