The paper identifies 38 cases of enzymes with different structures but identical functions, analyzing their sequence, structure, and mechanism to support convergent evolution.

bioRxiv · Apr 8, 2024Evolutionary Biology

Distinct regions within SAP25 recruit O-linked glycosylation, DNA demethylation, and ubiquitin ligase and hydrolase activities to the Sin3/HDAC complex

P. Goswami, C. Banks, J. Thornton, B. Bengs, M. E. Sardiu, L. Florens, M. Washburn

The paper identifies distinct regions of SAP25 that recruit O-GlcNAc transferase, TET methylcytosine dioxygenases, and ubiquitin ligase/hydrolase activities to the Sin3/HDAC complex.

bioRxiv · Mar 5, 2024Biochemistry

The durability of long-lasting insecticidal nets treated with and without piperonyl butoxide (PBO) in Uganda.

F. Mechan, A. Katureebe, V. Tuhaise, M. Mugote, A. Oruni, I. Onyige, K. Bumali, J. Thornton, K. Maxwell, M. Kyohere, M. R. Kamya, P. Mutungi, S. P. Kigozi, A. Yeka, J. Opigo, , A. Lynd

This study compares the durability and bioefficacy of PBO-treated and pyrethroid-only LLINs in Uganda, finding that PBO content declines over time, reducing bioefficacy against resistant mosquitoes.

bioRxiv · Feb 17, 2022 · PreprintZoology