L. Florens

Distinct regions within SAP25 recruit O-linked glycosylation, DNA demethylation, and ubiquitin ligase and hydrolase activities to the Sin3/HDAC complex

The paper identifies distinct regions of SAP25 that recruit O-GlcNAc transferase, TET methylcytosine dioxygenases, and ubiquitin ligase/hydrolase activities to the Sin3/HDAC complex.

A Potent Kalihinol Analogue Disrupts Apicoplast Function and Vesicular Trafficking in P. falciparum Malaria.

This paper identifies MED6-189, a potent antimalarial compound that disrupts apicoplast function and vesicular trafficking in P. falciparum, showing efficacy against drug-resistant strains and demonstrating a unique mechanism of action.

PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum

This study shows PfMORC regulates chromatin structure and gene repression in Plasmodium falciparum, essential for parasite survival and a potential target for antimalarial drugs.

Serial Capture Affinity Purification and Integrated Structural Modeling of the H3K4me3 Binding and DNA Damage Related WDR76:SPIN1 Complex

The paper uses SCAP to isolate the WDR76:SPIN1 complex, identifies H3K4me3 binding, and shows its role in DNA damage response through structural modeling and interaction network analysis.

A Borrelia burgdorferi LptD Homolog Facilitates Flipping of Surface Lipoproteins Through the Spirochetal Outer Membrane

This study identifies BB0838 as essential for surface lipoprotein translocation in Borrelia burgdorferi, showing it facilitates flipping of lipoproteins through the outer membrane.

Distinct states of nucleolar stress induced by anti-cancer drugs

This study identifies distinct nucleolar stress states induced by various anticancer drugs and characterizes their molecular and morphological effects.

An apical protein, Pcr2, is required for persistent movement by the human parasite Toxoplasma gondii

This study identifies Pcr2 as a critical protein for movement and invasion in Toxoplasma gondii, showing that its absence impairs egress and tissue destruction.

Metabolic reprogramming underlies cavefish muscular endurance despite loss of muscle mass and contractility

This paper shows cavefish have reduced muscle mass and contractility but increased muscular endurance due to metabolic reprogramming involving glycogen utilization.

Hypoxic response is driven by the BAF form of SWI/SNF

The paper shows hypoxia alters SWI/SNF complex composition, with BAF subunits retained and others downregulated, affecting HIF target gene induction and cell survival.

The C. elegans ASPP homolog APE-1 is a junctional protein phosphatase 1 modulator

The paper identifies APE-1 as a modulator of PP1 activity in C. elegans, showing it localizes PP1 to junctions and modulates phosphatase output through its ankyrin repeats.

Stem cell-free therapy for glaucoma to preserve vision

This study demonstrates that stem cell-derived secretome reduces intraocular pressure and protects retinal ganglion cells in glaucoma models through COX2-PGE2 pathway activation and extracellular matrix remodeling.

Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing

This study reveals the structural basis of SETD2 methyltransferase interaction with hnRNP L paralogs, showing how a leucine pair in SETD2 interacts with hnRNP L RRM2 and affects splicing regulation.

Yeast Nuak1 phosphorylates histone H3 threonine 11 in low glucose stress conditions by the cooperation of AMPK and CK2 signaling

The paper identifies Tda1 as the kinase responsible for H3pT11 phosphorylation under low glucose stress, showing its regulation by AMPK and CK2 signaling in yeast.

Harnessing Ionic Selectivity In Acetyltransferase Chemoproteomic Probes

The paper develops a CoA-based chemoproteomic strategy to optimize probe selectivity and evaluates its application in assessing small molecule acetyltransferase inhibitors.

The histone methyltransferase SETD2 couples transcription and splicing by engaging pre-mRNA processing factors through its SHI domain

This study identifies SETD2 as a factor that interacts with hnRNP L to regulate alternative splicing by linking transcription and splicing through its SHI domain.

The plasticity of the pyruvate dehydrogenase complex confers a labile structure that is associated with its catalytic activity

This study shows that the pyruvate dehydrogenase complex (PDC) is salt-labile and structurally variable, with activity affected by ionic strength.

STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation

The paper shows STRIPAK directs PP2A to dephosphorylate MAP4K4, promoting oncogenic transformation via YAP1 activation.

Integrative Modeling of a Sin3/HDAC Complex Sub-structure

The paper determines the spatial arrangement of Sin3 subunits around SIN3A using cross-linking and mass spectrometry, revealing their relative positions and interactions.

A systems chemoproteomic analysis of acyl-CoA/protein interactions

The paper develops a chemoproteomic platform to analyze acyl-CoA/protein interactions and identifies biological processes affected by acetyl-CoA levels.

Ataxin-7 and non-stop coordinate SCAR protein levels, subcellular localization, and actin cytoskeleton organization

BRK Phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG and metastatic potential.

This study shows BRK phosphorylates SMAD4, leading to its proteasomal degradation and inhibition of the tumor suppressor FRK, which promotes metastasis.

The ULK1-FBXW5-SEC23B nexus controls autophagy

This study identifies the ULK1-FBXW5-SEC23B pathway as a regulator of autophagy by controlling COPII localization and SEC23B stability during nutrient starvation.

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation

This study identifies RUNX1 and RUNX3 as proteins that protect IKZF1 and IKZF3 from lenalidomide-induced degradation, thereby reducing the effectiveness of lenalidomide in multiple myeloma.

A chemoproteomic portrait of the oncometabolite fumarate

This study maps fumarate's covalent targets using chemoproteomic probes and identifies cysteine residues affected by fumarate or FH mutations in HLRCC cells.

The Human Cytoplasmic Dynein Interactome Reveals Novel Activators Of Motility

The paper identifies ninein and ninein-like as new dynein activators using BioID, revealing their role in cargo binding and motility.