FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation
D. Chen, A. Wosztyl, V. Mullapudi, S. Bali, J. Vacquer-Alicea, S. Melhem, H. Seelaar, J. Van Swieten, M. I. Diamond, L. A. Joachimiak
This study investigates how the FTD-tau S320F mutation stabilizes local structure and promotes amyloid motif-dependent aggregation through allosteric effects.
bioRxiv · Aug 11, 2022 · PreprintBiophysics