Author

A. Wosztyl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:comparative / phylogenetic analysis· 1 Approach:statistical model· 1

Frequent Co-Authors

d. chen· 2 shared L. A. Joachimiak· 2 shared S. Bali· 2 shared H. Seelaar· 1 shared J. Chen· 1 shared J. Rizo· 1 shared J. Vacquer-Alicea· 1 shared J. Van Swieten· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

d. chen

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2 papers

Recent·Most cited

Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context

S. Bali, R. Singh, P. M. Wydorski, N. van Nuland, A. Wosztyl, V. A. Perez, d. chen, J. Chen, J. Rizo, L. A. Joachimiak

This study shows that tau aggregation can be reduced by modifying sequences near the PGGG β-turn motif, while maintaining microtubule binding, offering therapeutic insights for neurodegenerative diseases.

bioRxiv · Dec 13, 2023Biophysics

FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation

D. Chen, A. Wosztyl, V. Mullapudi, S. Bali, J. Vacquer-Alicea, S. Melhem, H. Seelaar, J. Van Swieten, M. I. Diamond, L. A. Joachimiak

This study investigates how the FTD-tau S320F mutation stabilizes local structure and promotes amyloid motif-dependent aggregation through allosteric effects.

bioRxiv · Aug 11, 2022 · PreprintBiophysics