Cancer BiologybioRxivPreprint
Co-occurring mutations in the POLE exonuclease and non-exonuclease domains define a unique subset of highly mutagenic tumors.
S. S. Shah, E. V. Demidova, S. Ringenbach…·S. Arora
The paper identifies co-occurring POLE mutations in both exonuclease and non-exonuclease domains as a novel driver of ultra-high tumor mutation burden in certain cancers.
DOI 10.1101/2022.12.15.520593