S. S. Shah

Co-occurring mutations in the POLE exonuclease and non-exonuclease domains define a unique subset of highly mutagenic tumors.

The paper identifies co-occurring POLE mutations in both exonuclease and non-exonuclease domains as a novel driver of ultra-high tumor mutation burden in certain cancers.

Identification of Cancer-Associated Fibroblasts in Glioblastoma and Defining Their Pro-tumoral Effects

The paper identifies cancer-associated fibroblasts in glioblastoma and shows their pro-tumoral effects through interactions with glioblastoma stem cells.

A super-resolution protocol to correlate structural underpinnings of fast second-messenger signalling in primary cell types

The paper describes a correlative imaging protocol to visualize calcium signals and ryanodine receptors at nanoscale resolution in primary cells.

Role of c-Met/β1 integrin complex in the metastatic cascade

This study identifies the c-Met/β1 integrin complex as a driver of breast cancer intravasation and bone metastasis, suggesting therapeutic targeting could prevent metastases.