M. J. Hall

Photoprotective melanin is maintained within keratinocytes in a storage lysosome

The paper shows melanin-containing phagosomes in keratinocytes mature into storage lysosomes called melanokerasomes, which retain melanin for long-term photoprotection.

Co-occurring mutations in the POLE exonuclease and non-exonuclease domains define a unique subset of highly mutagenic tumors.

The paper identifies co-occurring POLE mutations in both exonuclease and non-exonuclease domains as a novel driver of ultra-high tumor mutation burden in certain cancers.

Mircubactin B rescues the lethal effect of cell wall biosynthesis mutations in Bacillus subtilis.

The paper identifies mirubactin B, a compound that rescues growth defects in Bacillus subtilis rod-complex mutants, showing activity beyond simple iron sequestration.

Reconstructed human pigmented skin/epidermis models achieve epidermal pigmentation through melanocore transfer.

The paper demonstrates that 3D reconstructed human pigmented skin models exhibit epidermal pigmentation through melanocore transfer, comparable to human skin.

FORMATION OF LIPOFUSCIN-LIKE AUTOFLUORESCENT GRANULES IN THE RETINAL PIGMENT EPITHELIUM REQUIRES LYSOSOME DYSFUNCTION

This study shows that lysosomal dysfunction leads to incomplete degradation of photoreceptor outer segments and accumulation of autofluorescent granules in RPE cells.

Genetic structure at national and regional scale in a long-distance dispersing pest organism, the bird cherry-oat aphid Rhopalosiphum padi

This study analyzes the genetic structure of the bird cherry-oat aphid across Great Britain, finding two genetic clusters and no evidence of population evolution.