Boosting heterologous protein production yield by adjusting global nitrogen and carbon metabolic regulatory networks in Bacillus subtilis
H. Cao, J. Villatoro-Hernandez, R. D. O. Weme, E. Frenzel, O. P. Kuipers
This study improves heterologous protein production in Bacillus subtilis by rewiring nitrogen and carbon metabolic regulatory networks through mutations in CodY and CcpA, increasing yields up to 290%.
bioRxiv · May 10, 2018Bioengineering