BioengineeringbioRxiv
Boosting heterologous protein production yield by adjusting global nitrogen and carbon metabolic regulatory networks in Bacillus subtilis
H. Cao, J. Villatoro-Hernandez, R. D. O. Weme…·O. P. Kuipers
This study improves heterologous protein production in Bacillus subtilis by rewiring nitrogen and carbon metabolic regulatory networks through mutations in CodY and CcpA, increasing yields up to 290%.
DOI 10.1016/j.ymben.2018.08.001