Single-cell RNA-Seq analysis reveals dual sensing of HIV-1 in blood Axl+ dendritic cells
F. Brouiller, F. Nadalin, O. Aït-Mohamed, P.-E. Bonte, C. Delaugerre, J.-D. Lelievre, F. Ginhoux, N. RUFFIN, P. BENAROCH
This study identifies two distinct transcriptional responses in Axl+ dendritic cells to HIV-1, mediated by NF-κB and STAT1/2 pathways, with implications for viral transmission and immune activation.
bioRxiv · Jan 3, 2022Immunology