Benefits of Collisional Cross Section Assisted Precursor Selection (caps-PASEF) for Cross-linking Mass Spectrometry
B. Steigenberger, H. W. P. van den Toorn, E. Bijl, J.-F. Greisch, O. Raether, M. Lubeck, R. J. Pieters, A. J. R. Heck, R. A. Scheltema
The paper demonstrates that ion mobility improves cross-linking mass spectrometry by separating mono-linked peptides from cross-linked peptide pairs, increasing detected cross-linked peptides by 50-70%.
bioRxiv · Apr 16, 2020Biochemistry