Osteopontin and iCD8α cells promote intestinal intraepithelial lymphocytes homeostasis
A. Nazmi, M. Greer, K. L. Hoek, M. B. Piazuelo, J.-H. Weitkamp, D. Olivares-Villagomez
This study shows osteopontin supports IEL homeostasis via CD44, with iCD8 cells mediating this effect, and osteopontin deficiency leads to reduced IEL numbers and increased intestinal inflammation.
bioRxiv · Dec 20, 2019Immunology