Parkinson's disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM
K. Zhao, Y.-J. Lim, Z. Liu, H. Long, Y. Sun, J.-J. Hu, C. Zhao, Y. Tao, X. Zhang, D. Li, Y.-M. Li, C. Liu
The paper determines the cryo-EM structure of phosphorylated α-synuclein fibrils at Tyr39, revealing structural changes linked to Parkinson's disease pathology.
bioRxiv · Apr 13, 2020Biophysics