Y. Tao

SON-dependent nuclear speckle rejuvenation alleviates proteinopathies

This study identifies pyrvinium pamoate as a compound that rejuvenates nuclear speckles, improving protein quality control and reducing YAP1 activity, thereby alleviating proteinopathies in pre-clinical models.

Structural insights into physiological activation and antagonism of melanin-concentrating hormone receptor MCHR1

This study presents cryo-EM structures of MCHR1 in active and inactive states, revealing ligand recognition and activation mechanisms to aid drug development.

3D Bioprinting of Human Neural Tissues with Functional Connectivity

This study develops a 3D bioprinting platform to create human neural tissues with functional connectivity, showing differentiation into neurons and astrocytes and forming functional circuits.

The Role of Rhizosphere Microorganisms and CNPS Genes in Shaping Nutritional Traits of Capsicum

This study examines how rhizosphere microorganisms and CNPS genes affect nutrient content in pepper plants, finding that bacterial communities and specific genes significantly influence nutrient absorption and accumulation.

Blocker-SELEX: A Structure-guided Strategy for Developing Inhibitory Aptamers Disrupting Undruggable Transcription Factor Interactions

This paper introduces Blocker-SELEX, a structure-guided method to design inhibitory aptamers that disrupt transcription factor interactions, demonstrating efficacy against SCAF4/SCAF8-RNAP2 and WDR5-MYC complexes.

Potential clinical value and influence of conductivity in conductive cardiac patches for reducing post-MI arrythmia risks

This study evaluates the clinical value of conductive cardiac patches by testing different conductivities and shows that higher conductivity reduces arrhythmia risks in post-MI hearts.

Neratinib Synergizes with Trastuzumab Antibody Drug Conjugate or with Vinorelbine to Treat HER2 Mutated Breast Cancer Patient Derived Xenografts and Organoids.

The paper tests neratinib combinations with T-DM1 and vinorelbine in HER2 mutated breast cancer PDX models and organoids, finding synergistic effects that could inform clinical trials.

A novel nested gene Aff3ir participates in vascular remodelling by enhancing endothelial cell differentiation in mice

This study identifies Aff3ir as a novel gene involved in endothelial cell differentiation by enhancing vascular stem/progenitor cell differentiation in mice.

Robust Small Molecule-Aided Cardiac Reprogramming Systems Selective to Cardiac Fibroblasts

This study identifies a chemical combination that enhances cardiac reprogramming of fibroblasts into cardiomyocytes with improved selectivity and efficiency.

SARS-CoV-2 Omicron infection augments the magnitude and durability of systemic and mucosal immunity in triple-dose CoronaVac recipients

This study examines immune responses in CoronaVac-vaccinated individuals after Omicron infection, showing enhanced antibody and cellular immunity compared to unvaccinated controls.

Kin selection underpins family dynamics in rural China

The study uses an evolutionary game model and rural Chinese family data to show that kin selection influences family size by adjusting co-resident members to maintain relatedness and inclusive fitness.

Human TUBA1B short open reading frame product regulates cancer cell growth via importin-β

This study identifies TUBA1B-sORF1, a novel protein from the TUBA1B gene, which promotes cancer cell growth by facilitating nuclear translocation of β-catenin.

Lymphotoxin-β Promotes Bone Colonization and Osteolytic Outgrowth of Indolent Bone Metastatic cells of Breast Cancer

This study identifies lymphotoxin-β as a key factor promoting bone colonization and osteolytic outgrowth of breast cancer metastatic cells.

Phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures

This study shows that phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures with different neurotoxicity and propagation properties.

HMGB1 acts as an agent of host defense at the gut mucosal barrier

This study identifies HMGB1 as a host defense molecule in the gut mucosal barrier that targets bacterial adhesins to prevent microbial invasion and adhesion.

SARS-CoV-2 exposure in Norway rats (Rattus norvegicus) from New York City

The paper tests SARS-CoV-2 exposure in NYC rats, finding 16.5% seropositive and partial genomes in some, and shows rat susceptibility to Alpha, Delta, and Omicron variants.

An alternative malonyl-CoA producing pathway in nature

The paper identifies an alternative pathway for malonyl-CoA production using oxaloacetate dehydrogenase in Streptomyces, enabling efficient bioproduction of malonyl-CoA-derived chemicals in E. coli.

Leveraging PDE solver for predicting transient space-use dynamics in ecological and epidemiological systems

The paper introduces a numerical framework using PDE solvers to predict transient space-use dynamics in ecological and epidemiological systems, demonstrating its application in movement ecology.

Intestinal Epithelial Heat Shock Protein 25/27 integrates host and microbial drivers of mucosal restitution following inflammatory injury

This study identifies Hsp25/27 as a key mediator of mucosal healing by integrating host and microbial signals in intestinal epithelial cells following inflammatory injury.

A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-Cov-2 virus and Omicron variant through a unique binding mode

This paper reports a synthetic nanobody, C5G2, that neutralizes SARS-CoV-2 and Omicron variants with high potency through a unique binding mechanism.

Enhanced photosynthetic efficiency for increased carbon assimilation and woody biomass production in hybrid poplar INRA 717-1B4

This study enhances photosynthetic efficiency in hybrid poplar trees using a photorespiration bypass pathway, resulting in increased biomass production.

RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes

This study identifies RFX6 as a key regulator of β cell dysfunction in early type 2 diabetes through multi-omics analysis of human pancreatic tissue.

Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines

This study evaluates how well antibodies from mRNA vaccines neutralize SARS-CoV-2 variants, finding that Omicron shows the most escape but booster doses maintain moderate neutralizing activity.

The special and general mechanism of cyanobacterial harmful algal blooms

The paper examines the special and general mechanisms of cyanobacterial harmful algal blooms, identifying ecological and evolutionary factors that enable cyanobacteria to dominate under eutrophic conditions.

Different structures and pathologies of alpha-synuclein fibrils derived from preclinical and postmortem patients of Parkinson's disease

This study compares alpha-synuclein fibril structures from preclinical and postmortem Parkinson's disease patients, showing structural and pathological differences in fibril conformation during disease progression.

Miniature inverted-repeat transposable elements drive rapid microRNA diversification in angiosperms

The paper identifies MITEs as a source of new miRNAs in angiosperms, showing they rapidly diversify miRNA repertoires through transposition and transcription.

OsciDrop: A versatile on-demand droplet generator

OsciDrop generates size-tunable, monodisperse droplets on demand without microfabrication, enabling chip-free droplet assays for applications like virus quantification.

The Copper Responsive Transcription Factor SPL7 Represses Key Abscisic Acid Biosynthetic Genes to Balance Growth and Drought Tolerance

High copper availability represses SPL7, releasing its suppression on key ABA biosynthetic genes and leading to increased ABA accumulation that inhibits growth but enhances drought tolerance.

Somatic mutations of activated signaling genes, transcription factors, or tumor suppressors are a precondition for leukemic transformation from myelodysplastic syndromes: a sequencing analysis of 64 paired samples

Integration of embryo-endosperm interaction into a holistic and dynamic picture of seed development using a rice mutant with notched-belly grains

The paper investigates embryo-endosperm signaling in rice using a mutant to identify regulatory pathways affecting endosperm development and proposes a new staging system for rice seed development.