Author

J.-R. Yang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:chromatin & epigenetic regulation· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:comparative / phylogenetic analysis· 1 Approach:deep learning· 1

Frequent Co-Authors

X. Chen· 3 shared H. Zhao· 2 shared C. Maclean· 1 shared C. Park· 1 shared F. Chen· 1 shared G. Yu· 1 shared G.-b. Tian· 1 shared H. Zhu· 1 shared

Activity by Year

2016-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersEvolutionary Biology

X. Chen

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Author profile →

5 papers

Recent·Most cited

The fitness landscape of the mobilized colistin resistance gene mcr-1

Z. Guo, S. Feng, L. Liang, J. Li, L.-L. Zhong, H. Zhao, G.-b. Tian, J.-R. Yang

The paper generates and analyzes an mcr-1 mutant library to assess the impact of mutations on colistin resistance, finding that most mutations in the catalytic domain reduce resistance.

bioRxiv · Jul 21, 2022 · PreprintEvolutionary Biology

A high-density lineage tree reveals dynamics of expression differences accumulation in nondifferentiating clonal expansion

F. Chen, Z. Li, X. Zhang, P. Wu, W. Yang, X. Chen, J.-r. Yang

The paper develops a method to track transcriptome differences in clonal expansion and shows constrained expression noise dynamics during cell divisions.

bioRxiv · Nov 24, 2021Cell Biology

The Evolution of Sex Chromosome Dosage Compensation in Animals

J. Chen, M. Wang, X. He, J.-R. Yang, X. Chen

This study analyzes S:A ratios across species to understand dosage compensation mechanisms in sex chromosomes, finding clade-specific patterns and supporting the sex chromosome insensitivity hypothesis.

bioRxiv · Jul 4, 2020Evolutionary Biology

Specificity of RNA folding and its association with evolutionarily adaptive mRNA secondary structure

G. Yu, H. Zhu, X. Chen, J.-R. Yang

The paper assesses RNA folding specificity in mRNA and noncoding RNA, finding that specific folding is more evolutionarily adaptive and functionally significant.

bioRxiv · Oct 11, 2018Evolutionary Biology

Intra- and inter-specific variations of gene expression levels in yeast are largely neutral

J.-R. Yang, C. Maclean, C. Park, H. Zhao, J. Zhang

The paper investigates gene expression variations in yeast and finds most are neutral, not adaptive, suggesting random mutations drive expression evolution.

bioRxiv · Nov 28, 2016Evolutionary Biology