C. MacLean

Regulatory fine-tuning and horizontal gene transfer stabilize mobile colistin resistance

This study shows how regulatory evolution and horizontal gene transfer stabilize mcr-1 resistance in E. coli despite fitness costs.

Antibiotic heteroresistance generated by multi-copy plasmids

This study shows that multi-copy plasmids in E. coli generate antibiotic heteroresistance through copy number variability, enabling transient resistance and population regeneration.

Off-target integron activity leads to rapid plasmid compensatory evolution in response to antibiotic selection pressure

The paper shows integron activity can drive plasmid evolution by causing off-target inversions that improve plasmid stability and fitness under antibiotic pressure.

Pre-existing chromosomal polymorphisms in pathogenic E. coli potentiate the evolution of antibiotic resistance by MCR-1 plasmid acquisition

The paper shows pre-existing lpxC polymorphisms in E. coli enhance the evolution of colistin resistance via MCR-1 plasmid acquisition through positive epistasis.

The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence

This study shows that colistin resistance in E. coli increases resistance to host antimicrobial peptides and virulence, highlighting risks of therapeutic AMP use.

Localized hypermutation drives the evolution of unstable colistin resistance in small populations of Pseudomonas aeruginosa

The paper investigates how colistin resistance evolves in Pseudomonas aeruginosa populations, finding localized hypermutation in pmrB and evidence of phenotypic plasticity.

Evolutionary processes driving the rise and fall of Staphylococcus aureus ST239, a dominant hybrid pathogen

This study investigates the evolutionary history of Staphylococcus aureus ST239, finding it originated before methicillin use and has low fitness, contributing to its decline.

Rapid evolution drives the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection

The paper tracks the rapid evolution of carbapenem resistance in P. aeruginosa during an acute infection, showing resistance rise and fall due to antibiotic treatment.

Integron activity accelerates the evolution of antibiotic resistance

This study shows that integron activity speeds up antibiotic resistance evolution in P. aeruginosa by enhancing cassette expression and removing redundant elements without harmful side effects.

Stochastic bacterial population dynamics prevent the emergence of antibiotic resistance from single cells

This paper shows that low antibiotic concentrations can prevent resistance emergence from single cells due to stochastic effects, challenging deterministic models.

Intra- and inter-specific variations of gene expression levels in yeast are largely neutral

The paper investigates gene expression variations in yeast and finds most are neutral, not adaptive, suggesting random mutations drive expression evolution.