Author

Jack Braithwaite

University of Nottingham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Chalmers Ronald· 2 shared Christopher Cannon· 2 shared H. T. EdwardsiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersBiochemistry

Chalmers Ronald

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Cas1 epistasis tunes conformational coupling to enhance CRISPR adaptation

H. T. Edwards, Christopher Cannon, Jack Braithwaite, Chalmers Ronald

The paper identifies a prespacer-coupling module in Cas1 that interacts with a conformational-coupling module, showing that epistatic interactions between substitutions enhance CRISPR adaptation activity.

bioRxiv · Aug 20, 2026 · PreprintBiochemistry

RecA status determines SOS- and RecBCD-dependent outcomes in CRISPR-Cas adaptation

H. T. Edwards, Christopher Cannon, Jack Braithwaite, Chalmers Ronald

This study shows that RecA status influences CRISPR-Cas adaptation through SOS response mechanisms in E. coli, with RecA loss enhancing adaptation via RecBCD-dependent DNA processing.

bioRxiv · Aug 20, 2026 · PreprintMicrobiology