Author

H. T. Edwards

University of NottinghamORCID 0000-0001-5121-8972Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:E. coli· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Chalmers Ronald· 2 shared Christopher Cannon· 2 shared Jack Braithwaite· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Chalmers Ronald

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BiochemistrybioRxivPreprintAug 20, 2026

Cas1 epistasis tunes conformational coupling to enhance CRISPR adaptation

H. T. Edwards, Christopher Cannon, Jack Braithwaite, Chalmers Ronald

The paper identifies a prespacer-coupling module in Cas1 that interacts with a conformational-coupling module, showing that epistatic interactions between substitutions enhance CRISPR adaptation activity.

DOI 10.64898/2026.08.20.745182

E. colistatistical model

𝕏 PostBluesky

MicrobiologybioRxivPreprintAug 20, 2026

RecA status determines SOS- and RecBCD-dependent outcomes in CRISPR-Cas adaptation

H. T. Edwards, Christopher Cannon, Jack Braithwaite, Chalmers Ronald

This study shows that RecA status influences CRISPR-Cas adaptation through SOS response mechanisms in E. coli, with RecA loss enhancing adaptation via RecBCD-dependent DNA processing.

DOI 10.64898/2026.08.20.745894

E. coliDNA methylation

𝕏 PostBluesky