The inhibition of the JNK2-Syntaxin-1A interaction neuroprotects against retinal degeneration
Marco Cimino, Jack Serkiz, Joanne K. Konstantopoulos, Annamaria Tisi, Pamela Cappelletti, Rita Maccarone, Rebecca M. Sappington, Marco Feligioni
The paper shows that inhibiting the JNK2-STX1A interaction with JGRi1 protects retinal ganglion cells from degeneration in multiple models.
bioRxiv · Sep 30, 2025 · PreprintNeuroscience