Medical-Grade Manuka Honey and Manuka Honey Extract Inhibit Mast Cell Degranulation through inhibition of MRGPRX2 expression: Potential Intravesical Agent for the Management of Interstitial Cystitis/Bladder Pain Syndrome?
Omar Abdelwahab, Kamaluddeen Garba, Laurie C.K. Lau, David Annandale Johnston, Andrew F. Walls, Hannah Markham, Brian R. Birch, Jackie C. Evans, Troy L. Merry, Bashir Abdulgader Lwaleed
This study shows that Medihoney and a sugar-free Manuka honey extract inhibit Substance P-induced mast cell degranulation by suppressing MRGPRX2 activation, suggesting their potential as therapies for IC/BPS.
bioRxiv · Aug 7, 2026 · PreprintImmunology