ImmunologybioRxivPreprint
Medical-Grade Manuka Honey and Manuka Honey Extract Inhibit Mast Cell Degranulation through inhibition of MRGPRX2 expression: Potential Intravesical Agent for the Management of Interstitial Cystitis/Bladder Pain Syndrome?
Omar Abdelwahab, Kamaluddeen Garba, Laurie C.K. Lau…·Bashir Abdulgader Lwaleed
This study shows that Medihoney and a sugar-free Manuka honey extract inhibit Substance P-induced mast cell degranulation by suppressing MRGPRX2 activation, suggesting their potential as therapies for IC/BPS.
DOI 10.64898/2026.08.02.742332