Author

Jacob G. Jansen

Leiden University Medical Center

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Molecular Biology· 1

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Approach:experimental assay· 1

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Anastasia Tsaalbi-Shtylik· 1 shared Daniel C. de Groot· 1 shared Heinz JacobsiD· 1 shared Karoly Szuhai· 1 shared Niels de WindiD· 1 shared Piya Temviriyanukul· 1 shared Sandrine van Hees-Stuivenberg· 1 shared

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Anastasia Tsaalbi-Shtylik

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1 paper

Recent·Most cited

Clastogenesis by nucleotide lesions requires the completion of two cell cycles.

Jacob G. Jansen, Piya Temviriyanukul, Daniel C. de Groot, Karoly Szuhai, Sandrine van Hees-Stuivenberg, Anastasia Tsaalbi-Shtylik, Heinz Jacobs, Niels de Wind

The paper identifies a delayed mechanism of clastogenesis where unrepaired nucleotide lesions in single-stranded DNA persist through mitosis and generate clastogenic DSBs during the subsequent S phase.

bioRxiv · Dec 18, 2025 · PreprintMolecular Biology