Heinz Jacobs

The paper identifies a delayed mechanism of clastogenesis where unrepaired nucleotide lesions in single-stranded DNA persist through mitosis and generate clastogenic DSBs during the subsequent S phase.

This study shows that DOT1L maintains CD8 T cell identity and restricts their cytotoxic potential by preventing NK-cell features and enhancing anti-tumor reactivity.

This study shows that targeting DOT1L and EZH2 together disrupts the germinal center identity of GCB-DLBCL cells, leading to a cell-identity crisis and reduced tumor growth in vivo.

The paper investigates the molecular and genomic effects of a global DNA damage tolerance defect, identifying type 3 deletions as a mutational signature of replication stress.

This study shows that multiple 9-1-1 complexes are essential for meiotic DSB repair, homolog synapsis, and ATR signaling in mammals.

This study identifies USP15 as critical for hematopoietic stem cell maintenance and genome integrity, showing its depletion impairs expansion and increases genotoxic stress in leukemia cells.