Reduction of Glut1 in retinal neurons but not the RPE alleviates polyol accumulation and normalizes early characteristics of diabetic retinopathy.
Nicholas C. Holoman, Jacob J. Aiello, Timothy D. Trobenter, Matthew J. Tarchick, Michael R. Kozlowski, Emily R. Makowski, Darryl C. De Vivo, Charandeep Singh, Jonathan E. Sears, Ivy S. Samuels
This study shows that reducing Glut1 in retinal neurons, but not the RPE, reduces polyol accumulation and prevents early diabetic retinopathy features in mice.
Journal of Neuroscience · Feb 23, 2021Peer-reviewedNeuroscience