Evidence for Alternative Complement Cascade Activation in Primary CNS Vasculitis
Caleigh Mandel-Brehm, Hanna Retallack, Giselle M. Knudsen, Alex Yamana, Rula A. Hajj-Ali, Leonard H. Calabrese, Tarik Tihan, Hannah A. Sample, Kelsey C. Zorn, Mark P. Gorman, Jennifer Madan Cohen, Antoine G. Sreih, Jacqueline F. Marcus, S. Andrew Josephson, Vanja C. Douglas, , Joseph L. DeRisi
The paper analyzes cerebrospinal fluid proteomes to identify complement pathway activation in PACNS, suggesting C5 inhibitors as potential therapies.
bioRxiv · May 24, 2018 · PreprintImmunology