Synergistic cytotoxicity with Chk1/Chk2-inhibitor prexasertib in small cell lung cancer following lurbinectedin-induced G2/M-checkpoint activation
Ashley Sanchez Sevilla Uruchurtu, Audrey Y. Su, Harshita Ganga, Shengliang Zhang, Ameen Raissi, Kevin Kwon, Tej Tummala, Tyler J. Roady, Jacqueline Moreno, Patrycja M. Dubielecka, Christopher G. Azzoli, Wafik S. El‐Deiry
This paper shows that combining prexasertib with lurbinectedin synergistically kills small cell lung cancer cells by disrupting G2/M checkpoint responses.
bioRxiv · Aug 7, 2026 · PreprintCancer Biology