A regulatory module driving the recurrent evolution of irreducible molecular complexes.
Polina Tikanova, James Julian Ross, Andreas Hagmüller, Florian Pühringer, Pinelopi Pliota, Daniel Krogull, Valeria Stefania, Manuel Hunold, Alevtina Koreshova, Anja Koller, Ivanna Ostapchuk, Jacqueline Okweri, Joseph Gokcezade, Peter Duchek, Gang Dong, , Alejandro R. Burga
The paper investigates how interdependent protein interactions evolve by studying toxin-antidote elements, finding that toxins and antidotes can arise simultaneously through the duplication of a regulatory module.
Nature Ecology & Evolution · Nov 17, 2025Peer-reviewedGenomics