Author

Joseph Gokcezade

Institute of Molecular Biotechnology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alejandro R. BurgaiD· 4 shared Andreas Hagmüller· 4 shared Peter Duchek· 4 shared Alevtina KoreshovaiD· 3 shared Daniel KrogulliD· 3 shared Gang DongiD· 3 shared Pinelopi PliotaiD· 3 shared Polina TikanovaiD· 3 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersEvolutionary Biology

Alejandro R. BurgaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Conflicts and coalitions among selfish toxin-antidote elements shape the evolution of hyperdivergent haplotypes

Alevtina Koreshova, Andreas Hagmüller, Arda Kara, Pinelopi Pliota, Tianhua Liao, George Kobakhidze, Joseph Gokcezade, Peter Duchek, Christian Braendle, Gang Dong, Alejandro R. Burga

The paper investigates genetic conflict between toxin-antidote elements in C. tropicalis, revealing their role in shaping hyperdivergent haplotypes through competition and recombination.

bioRxiv · Oct 26, 2026 · PreprintEvolutionary Biology

Evolution of an Aurora Kinase A Inhibitor from an Essential tRNA Synthetase

James Julian Ross, Polina Tikanova, Andreas Hagmüller, Daniel Krogull, Keyu Xiao, Casper van Bavel, Till Balla, Tianhua Liao, Kolin Angello Echano, Joseph Gokcezade, Peter Duchek, Danny D. Nedialkova, Rob Jelier, Gang Dong, Alejandro R. Burga

The paper shows how a duplicated tRNA synthetase evolved into a novel toxin by losing its ancestral function and acquiring a new role in targeting Aurora kinase A.

bioRxiv · Jun 10, 2026 · PreprintEvolutionary Biology

A regulatory module driving the recurrent evolution of irreducible molecular complexes.

Polina Tikanova, James Julian Ross, Andreas Hagmüller, Florian Pühringer, Pinelopi Pliota, Daniel Krogull, Valeria Stefania, Manuel Hunold, Alevtina Koreshova, Anja Koller, Ivanna Ostapchuk, Jacqueline Okweri, Joseph Gokcezade, Peter Duchek, Gang Dong, , Alejandro R. Burga

The paper investigates how interdependent protein interactions evolve by studying toxin-antidote elements, finding that toxins and antidotes can arise simultaneously through the duplication of a regulatory module.

Nature Ecology & Evolution · Nov 17, 2025Peer-reviewedGenomics

The evolution of an RNA-based memory of self in the face of genomic conflict

Pinelopi Pliota, Hana Marvanova, Alevtina Koreshova, Yotam Kaufman, Polina Tikanova, Daniel Krogull, Andreas Hagmüller, Sonya A. Widen, Dominik Handler, Joseph Gokcezade, Peter Duchek, Julius Brennecke, Eyal Ben‐David, Alejandro R. Burga

The paper investigates how selfish toxin-antidote elements evade silencing in C. tropicalis by showing maternal mRNA licenses zygotic expression through counteracting piRNAs.

bioRxiv · Jun 17, 2022 · PreprintGenetics