A conserved isoleucine gates the diffusion of small ligands to the active site of NiFe CO-dehydrogenase
Laura V. Opdam, Marta Meneghello, Chloé Guendon, Jade Chargelegue, Andrea Fasano, Aurore Jacq‐Bailly, Christophe Léger, Vincent Fourmond
The paper investigates the role of conserved isoleucine 563 in controlling ligand access to the active site of NiFe CO-dehydrogenase through site-directed mutagenesis.
bioRxiv · May 10, 2026 · PreprintBiochemistry