Author

Christophe Léger

Centre National de la Recherche ScientifiqueORCID 0000-0002-8871-6059Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:electrophysiology· 1

Frequent Co-Authors

Laura V. OpdamiD· 2 shared Vincent FourmondiD· 2 shared Andrea FasanoiD· 1 shared Aurore Jacq‐Bailly· 1 shared Chloé Guendon· 1 shared Holger DobbekiD· 1 shared Jade Chargelegue· 1 shared Marta MeneghelloiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 26 mutual co-author links

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2 shared papersBiochemistry

Laura V. OpdamORCID

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2 papers

Recent·Most cited

BiochemistryAngewandte Chemie International EditionPeer-reviewedMay 23, 2026

Correspondence on "Fortification of FeS Clusters Reshapes Anaerobic CO Dehydrogenase into an Air-Viable Enzyme ThroughMultilayered Sealing of O2 Tunnels"

Laura V. Opdam, Peter Gebhardt, Christophe Léger…·Vincent Fourmond

The paper challenges claims about oxygen resistance in CO dehydrogenase mutants by showing A559W and A559W/V610H variants are not more resistant than wild-type.

4 citations

electrophysiologyexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivPreprintMay 10, 2026

A conserved isoleucine gates the diffusion of small ligands to the active site of NiFe CO-dehydrogenase

Laura V. Opdam, Marta Meneghello, Chloé Guendon…·Vincent Fourmond

The paper investigates the role of conserved isoleucine 563 in controlling ligand access to the active site of NiFe CO-dehydrogenase through site-directed mutagenesis.

3 citations

experimental assay

𝕏 PostBluesky