Cardiac Myosin Activation Enhances Contractility While Preserving Myocardial Energetics Compared With β-Adrenergic Stimulation
Mohsin Rahim, Tomáš Baka, Huamei He, Sonette Steczina, Meredith A. Redd, James A. Balschi, Darren Ting‐Cheung Hwee, James J. Hartman, Fady I. Malik, Anne N. Murphy, Ivan Luptak
This study compares CK-138 and dobutamine, showing CK-138 improves cardiac contractility without worsening myocardial energetics, unlike dobutamine which depletes ATP and shifts metabolism toward glycolysis.
bioRxiv · Jun 18, 2026 · PreprintPhysiology