Author

Huamei He

Brigham and Women's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Organism:rat· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Joseph LoscalzoiD· 2 shared Niv VigderiD· 2 shared Amit Chandra· 1 shared Anne N. MurphyiD· 1 shared Bradley M. WertheimiD· 1 shared Clary B. ClishiD· 1 shared Darren Ting‐Cheung HweeiD· 1 shared Elena AronsiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

Joseph LoscalzoORCID

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Author profile →

3 papers

Recent·Most cited

2-Hydroxyglutarate Redirects Fatty Acid Partitioning to Mitigate Lipotoxic Stress and Preserve Metabolic Fuel

Niv Vigder, Amit Chandra, Nishith Shrimali, Sergey Tumanov, Vlad Elgart, Huamei He, Ryan M. Mulhern, Ram Prosad Chakrabarty, Navdeep S. Chandel, Stuart J. Cordwell, Steven P. Gygi, João A. Paulo, Joseph Loscalzo

This paper shows that 2-hydroxyglutarate (2HG) alters fatty acid partitioning, reducing lipotoxic stress by shifting fatty acids toward storage and away from oxidation and membrane synthesis.

bioRxiv · Aug 14, 2026 · PreprintCell Biology

Cardiac Myosin Activation Enhances Contractility While Preserving Myocardial Energetics Compared With β-Adrenergic Stimulation

Mohsin Rahim, Tomáš Baka, Huamei He, Sonette Steczina, Meredith A. Redd, James A. Balschi, Darren Ting‐Cheung Hwee, James J. Hartman, Fady I. Malik, Anne N. Murphy, Ivan Luptak

This study compares CK-138 and dobutamine, showing CK-138 improves cardiac contractility without worsening myocardial energetics, unlike dobutamine which depletes ATP and shifts metabolism toward glycolysis.

bioRxiv · Jun 18, 2026 · PreprintPhysiology

Branched chain α-ketoacids aerobically activate HIF1α signaling in vascular cells

Wusheng Xiao, Nishith M. Shrimali, Niv Vigder, William M. Oldham, Clary B. Clish, Huamei He, Samantha J. Wong, Bradley M. Wertheim, Elena Arons, Marcia C. Haigis, Jane A. Leopold, Joseph Loscalzo

This study identifies branched chain α-ketoacids (BCKAs) as novel signaling metabolites that activate HIF1α signaling in normoxia and modulate vascular smooth muscle cell function in pulmonary vascular disease.

Nature Metabolism · Oct 29, 2024Peer-reviewedCell Biology