Irregular nucleosome positioning governs a crystalline to liquid-like phase transition and tunes chromatin accessibility
Waad Albawardi, Matthew Thomas, Gert-Jan Kuijntjes, Hannah Amy Wheeldon, Artur P. Kaczmarczyk, James Allan, James Ding, Michael Chiang, Willem Vanderlinden, John van Noort, Davide Marenduzzo, Chris A. Brackley, Nick Gilbert
The paper shows that nucleosome positioning determines chromatin's physical state, with irregular positioning enabling accessibility for transcription while maintaining genome protection.
bioRxiv · Aug 25, 2026 · PreprintMolecular Biology