Author

James Brindle

Institute of Genetics and Cancer

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Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Grzegorz R. KudlaiD· 1 shared J O'Brien Stephen· 1 shared Joshua B. PlotkiniD· 1 shared Pragya MittaliD· 1 shared

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2018-2018 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperSynthetic Biology

Grzegorz R. KudlaORCID

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1 paper

Recent·Most cited

Codon usage influences fitness through RNA toxicity

Pragya Mittal, James Brindle, J O'Brien Stephen, Joshua B. Plotkin, Grzegorz R. Kudla

The paper shows that synonymous codon usage affects bacterial fitness through translation-independent RNA toxicity, identifying mRNA sequence determinants and suppressor strains.

Proceedings of the National Academy of Sciences · Aug 6, 2018Peer-reviewedSynthetic Biology