Author

Pragya Mittal

Institute of Genetics and CancerORCID 0000-0002-5881-3739Unclaimed ORCID profile · follow to get notified of new preprints

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Synthetic Biology· 1

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Assay:DNA methylation· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

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Grzegorz R. KudlaiD· 1 shared J O'Brien Stephen· 1 shared James Brindle· 1 shared Joshua B. PlotkiniD· 1 shared

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Grzegorz R. KudlaORCID

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Synthetic BiologyProceedings of the National Academy of SciencesPeer-reviewedAug 6, 2018

Codon usage influences fitness through RNA toxicity

Pragya Mittal, James Brindle, J O'Brien Stephen…·Grzegorz R. Kudla

The paper shows that synonymous codon usage affects bacterial fitness through translation-independent RNA toxicity, identifying mRNA sequence determinants and suppressor strains.

107 citationstop 3%

E. coliDNA methylation

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