Identification and Structural Characterization of a mutant KRAS-G12V specific TCR restricted by HLA-A3
Malcolm J. W. Sim, Ken‐ichi Hanada, Zachary Stotz, Zhiya Yu, Jinghua Lu, Paul Brennan, Max Quastel, Geraldine M. Gillespie, Eric O. Long, James C. Yang, Peter D. Sun
The paper identifies a TCR specific to KRAS-G12V neoantigen and characterizes its structural interaction with HLA-A3, revealing challenges in targeting this mutation.
bioRxiv · Feb 1, 2024Immunology