Malcolm J. W. Sim

This study shows TMEM33 limits progenitor-exhausted CD8+ T cells, enhances anti-tumor responses, and correlates with improved survival in melanoma patients.

This study develops a peptide-exchange system to efficiently study KIR binding to HLA-I molecules with peptide specificity.

The paper investigates tapasin-independent peptide editing by MHC-I molecules using molecular dynamics simulations, revealing an 'active displacement' mechanism that explains peptide selection and immunogenic epitope presentation.

The paper identifies a TCR specific to KRAS-G12V neoantigen and characterizes its structural interaction with HLA-A3, revealing challenges in targeting this mutation.