RAD52 underlies the synthetic-lethal relationship between BRCA1/2 and 53BP1 deficiencies and DNA polymerase theta loss.
Katarzyna Starowicz, George E. Ronson, Elizabeth J. Anthony, Lucy Clarke, Alexander J. Garvin, Andrew David Beggs, Celina Whalley, Matthew Edmonds, James F. J. Beesley, Joanna R. Morris
The paper identifies RAD52 as the mediator of synthetic-lethal interactions between BRCA1/2, 53BP1 deficiencies, and DNA polymerase theta loss in murine cells.
bioRxiv · Mar 20, 2022 · PreprintMolecular Biology