Ligand-induced and small molecule control of substrate loading in a hexameric helicase
Michael R. Lawson, Kevin Dyer, James M. Berger
This study investigates how bicyclomycin and nucleic acids modulate Rho's ring conformation, showing bicyclomycin inhibits ring closure while nucleic acids promote it, revealing mechanisms of substrate-dependent activity control.
bioRxiv · Aug 16, 2016Biochemistry